Journal of Vascular Surgery

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Updated: 9 hours 12 min ago

PC204 Enhancement of Reperfusion and Neovascularization in Mouse Hind Limb Gangrene Model by Novel Gene Therapy

June 1, 2017 - 00:00
The lack of a reliable animal hind limb gangrene model limits molecular investigation and preclinical treatment of critical limb ischemia. We sought to develop and characterize a mouse hind limb gangrene model and used it to assess the efficacy of novel gene therapy. We hypothesized that priming ischemic hind limb tissue with E-selectin/adeno-associated virus (AAV) would enhance therapeutic angiogenesis and attenuate gangrene.

PC202 Critical Role of Endothelial Notch1 Signaling in Atherosclerosis

June 1, 2017 - 00:00
Notch signaling plays pivotal roles in vascular development and cardiovascular disease. Our previous studies showed that the Notch pathway is activated in luminal endothelial cells at atherosclerotic plaques and results in proinflammatory response and senescence of endothelial cells, implicating a potential involvement of Notch signaling in atherosclerosis. Here, we investigate the role of Notch signaling in atherosclerosis using a genetic mouse model with inducible endothelial cell-specific Notch1 gene deletion on an apolipoprotein E (ApoE)-deficient background.

PC200 A Deacetylase Enzyme, Sirtuin 3, Plays a Major Role in Macrophage Inflammation and Wound Healing

June 1, 2017 - 00:00
Wound healing in chronic inflammatory diseases, such as diabetes, is impaired due to failed resolution of inflammation. Innate immune cells, particularly macrophages, play a significant role in the establishment of a regulated inflammatory response during wounding. Macrophage function is dictated by metabolism, which alters gene expression. The mitochondrial deacylase enzyme, Sirtuin 3 (SIRT3), was recently shown to suppress inflammatory signaling and decrease reactive oxygen species. Therefore, we investigated the role of SIRT3 in inflammation in peripheral wound macrophages.

PC198 Decreased CD26 Triggers the Differentiation of Monocytes Into Macrophages in Abdominal Aortic Aneurysm

June 1, 2017 - 00:00
CD26 is a 110-kDa glycoprotein that is expressed on numerous cell types and has multiple biological functions, including immune regulation, signal transduction, and apoptosis. We aimed to evaluate the expression of CD26 on mononuclear cells and its potential role in abdominal aortic aneurysm (AAA) evolution.

PC196 Effects of Linagliptin on Impaired Vessel Wall Healing After Arterial Injury in the Rat Diabetic Model

June 1, 2017 - 00:00
Diabetic patients suffer an increased risk of restenosis and late stent thrombosis after angioplasty, complications that are related to a defective re-endothelialization. Dipeptidyl peptidase-4 inhibitors have been suggested to exert direct effect on endothelial and smooth muscle cells (SMCs). Therefore, the objective was to study whether the dipeptidyl peptidase-4 inhibitor linagliptin could influence vascular repair and accelerate re-endothelialization after arterial injury in healthy and diabetic animals.

PC194 Ectopic Expression of Proprotein Convertase Subtilisin Kexin Type 9 by Smooth Muscular Cells Contributes to Aortic Dissection

June 1, 2017 - 00:00
Acute aortic dissection (AAD) is a common disease among the elderly. Although several risk factors of AAD have been reported, the molecular mechanism underlying AAD development remains to be elucidated. Recent findings based on lipid molecular analysis have made a major contribution to the understanding of the pathogenesis of cardiovascular diseases, and it is now recognized that metabolic abnormalities, especially serum dyslipidemia, correlate with AAD onset and aortic rupture. Proprotein convertase subtilisin/kexin type 9 (PCSK9) is a secreted enzyme that promotes the degradation of surface low-density lipoprotein (LDL) receptors (LDLRs), preventing the removal of LDL-cholesterol from the blood.

PC192 Effect of Iliac Vein Stenting of NIVLs on Venous Reflux Times

June 1, 2017 - 00:00
Iliac vein stenting of nonthrombotic iliac vein lesions (NIVL) is becoming a common treatment option for venous insufficiency. Treatment of venous insufficiency has been based on treatment of venous reflux. We examined the effect that iliac vein stenting had on reflux times prestenting and poststenting.

PC190 Diagnosis and Surgical Management of 16 Cases of Inferior Vena Cava Leiomyomatosis

June 1, 2017 - 00:00
This study reviewed our single-center experience in diagnosis and surgical treatment of inferior vena cava leiomyomatosis (IVL).

PC188 Outcomes of Iliac Vein Stenting in Proximal Venous Outflow Obstruction

June 1, 2017 - 00:00
This study evaluated the outcome of vein stent placement for chronic proximal venous outflow obstruction (PVOO) in order to improve patient selection, enhance technical approach, and better define quality measurements for these cases.

PC186 Silent Deep Venous Thrombosis: Associations With Proximal Venous Outflow Obstruction and Hypercoagulation Markers

June 1, 2017 - 00:00
The presence of a proximal venous outflow obstruction (PVOO) in the iliac vein has been observed during catheter-based interventions for acute deep venous thrombosis (DVT). It is not clear whether the proximal obstruction and the more distal DVT are causally related, even though stasis is a commonly known contributor to DVT. Stent placement in the iliac vein, an emerging intervention for chronic PVOO, has provided an unexpected opportunity to evaluate the relationship between PVOO in the iliac vein and DVT.

PC184 Delayed Conversion to Kissing Stent Configuration in the Setting of Unilateral Iliac Vein Stenting

June 1, 2017 - 00:00
Iliac vein stents are being increasingly used to treat chronic proximal venous outflow obstruction. Among patients with unilateral stenting in the proximal common iliac vein with extension into the inferior vena cava (IVC), a small number of patients presented with venous symptoms related to outflow obstruction of the contralateral common iliac vein. While the incidence of this complication of iliac vein stenting is unknown, this abstract presents one technical approach to this complication.

PC182 The Impact of Different Treatment Modalities on Recalcitrant Venous Ulcer Healing

June 1, 2017 - 00:00
Refractory venous ulcers are a national health issue, despite advances in wound care and compression therapy. We examined the impact of compression, correction of incompetent superficial and perforator veins, and dilatation of iliac stenosis/occlusion.

PC180 Endovascular Stent Repair of Traumatic Superficial Femoral and Popliteal Artery Injuries: An Analysis of the National Trauma Data Bank

June 1, 2017 - 00:00
Despite increasing use of endovascular stent repair of traumatic arterial injuries, such repair of superficial femoral artery (SFA) and popliteal artery (PA) injuries remains uncommon and poorly studied. We describe characteristics and outcomes of trauma patients with SFA and PA injuries repaired using endovascular stenting.

PC178 Age Associated With Mortality and Outcomes in Pediatric Vascular Trauma

June 1, 2017 - 00:00
Vascular injuries in children, although considered uncommon, have the potential for lifelong disability and present unique challenges in diagnosis and management due to anatomic and physiologic differences that vary with age. While vascular trauma is well studied in adult populations, data describing epidemiology in pediatric populations are sparse. The purpose of this study was to characterize incidence, patterns of injury, and outcomes using a multi-institutional national database.

PC176 Percutaneous Treatment of Popliteal Artery Occlusion After Posterior Knee Dislocation

June 1, 2017 - 00:00
To study describes an alternative revascularization approach to the gold standard reverse saphenous vein graft bypass for blunt traumatic popliteal artery injuries and demonstrates the feasibility and effectiveness of endovascular revascularization following posterior knee dislocation and subsequent arterial flow-limiting injury.

PC174 Outcomes in Endovascular Therapy for Popliteal Artery Injuries After Total Knee Replacement

June 1, 2017 - 00:00
Popliteal artery injury is a rare but serious complication of total knee arthroplasty (TKA). Incidence of these injuries ranges from 0.03% to 0.51%. Endovascular techniques are emerging as safe and effective approaches to popliteal injury. Cases of popliteal artery injury treated with endovascular therapies have been published, although there have been no large series or prospective analysis. In this study, we reviewed the experience and reported the safety and efficacy of popliteal stenting for management of the orthopedic vascular complication.

PC172 Coverage of the Left Subclavian Artery in Blunt Thoracic Aortic Injury Is Not Necessary to Achieve Aortic Healing in Patients With Short Proximal Landing Zones

June 1, 2017 - 00:00
Endovascular repair of the thoracic aorta (TEVAR) is the preferred treatment for blunt thoracic aortic injury (BTAI). Current stent grafts recommend a >20 mm proximal landing zone of healthy aorta, but these guidelines were based on treatment of aneurysms. Given the location of BTAI, this would often necessitate coverage of the left subclavian artery (LSA). In these often-healthier aortas, a shorter proximal landing zone may be acceptable. Current practice patterns still vary greatly regarding LSA coverage, and long-term effects of LSA coverage remain unknown.

PC170 Early vs Delayed Thoracic Endovascular Aortic Repair in Blunt Traumatic Aortic Injury

June 1, 2017 - 00:00
The traditional approach to stable blunt thoracic aortic injury (BTAI) endorsed by the Society for Vascular Surgery is urgent thoracic endovascular aortic repair (TEVAR). Recently, some studies have suggested a potential mortality benefit in stable BTAI patients repaired in a delayed manner (>24 hours). However, the indications for use of delayed TEVAR for BTAI are not well characterized, and its overall impact on patient survival remains poorly understood. We sought to determine whether delayed TEVAR would be associated with a decrease in mortality compared to early TEVAR in this population.

PC168 Acceleration of Diabetic Wound Healing With Adipose-Derived Stem Cells, Endothelial-Differentiated Stem Cells, and Topical-Conditioned Medium Therapy in a Swine Model

June 1, 2017 - 00:00
The goal of our study was to investigate the effect of adipose-derived stem cells (ASCs), endothelial differentiated (ED) ASCs, and various conditioned medium (CM) on wound healing in a diabetic swine model.

PC166 A Matched Case-Control Study on Open and Endovascular Treatment of Popliteal Artery Aneurysms

June 1, 2017 - 00:00
This study compared early and late results of open and endovascular management of popliteal artery aneurysm (PAA) in a retrospective single-center matched case-control study.