Journal of Vascular Surgery

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Updated: 9 hours 9 min ago

RS12 Flexible Stents Improve Renal Artery Branch Patency After Multibranched Endovascular Aortic Aneurysm Repair

June 1, 2017 - 00:00
Technical and short-term success with multibranched endovascular thoracoabdominal aortic aneurysm (TAAA) repairs (MBEVAR) is now routine. However, late branch occlusion, particularly renal branch occlusion, is a stubborn source of morbidity in the mid- to late-term. The aim of this study was to investigate the effect of renal branch stent type on midterm renal branch occlusion rates after MBEVAR of TAAA and pararenal aortic aneurysms (PRAA).

RS11 Incidence and Management of Iliac Artery Aneurysms Associated With Endovascular Treatment of Juxtarenal and Thoracoabdominal Aortic Aneurysms

June 1, 2017 - 00:00
Iliac artery aneurysms (IAA) associated with aortic aneurysms can complicate their management. The aim of this study was to evaluate the incidence, management, and outcomes of IAA associated with juxtarenal (JRAA) and thoracoabdominal aortic aneurysms (TAAA) treated with fenestrated/branched aortic endografts (F/B-EVAR).

RS10 Clinical Trial and Real-World Outcomes of Endovascular Iliac Aneurysm Repair With the Gore Iliac Branch Endoprosthesis (IBE)

June 1, 2017 - 00:00
The purpose of this study was to determine the midterm effectiveness of endovascular iliac artery aneurysm repair with hypogastric artery preservation using the Iliac Branch Endoprosthesis (IBE; W. L. Gore, Flagstaff, Ariz) in both multicenter trial and “real-world” use settings.

RS09 Prospective, Nonrandomized Assessment of Health-Related Quality of Life Changes in Patients Treated for Pararenal and Thoracoabdominal Aortic Aneurysms With Fenestrated and Branched Endografts

June 1, 2017 - 00:00
This study investigated changes in health-related quality of life (QOL) in patients treated for pararenal (PRA) and thoracoabdominal aortic aneurysms (TAAAs) with fenestrated-branched endovascular aortic repair (F-BEVAR).

SS32 Endovascular Repair of Postdissection Aneurysms Involving the Thoracoabdominal Aorta and Arch

June 1, 2017 - 00:00
We report the outcomes in the management of postdissection aneurysms of the aortic arch and thoracoabdominal aortic aneurysm (TAAA) segment treated with fenestrated and branched (complex) endografts.

PC234 Promoting Endothelial Cell Adhesion by Modulation of Prosthetic Surface Topography at the Nano-Scale

June 1, 2017 - 00:00
Nanotopographic surface engineering can produce a vascular graft surface with the potential to enhance endothelial cell (EC) adhesion. Our aim was to investigate EC response to different nanopit topographies compared to normal, focusing on cell adherence.

PC232 Finite-Element Analysis-Derived Biomechanical Rupture Risk Index Is Associated With Extracellular Matrix and Structure Organization in the Tunica Media of Abdominal Aortic Aneurysms

June 1, 2017 - 00:00
An abdominal aortic aneurysm (AAA) ruptures if the vessel wall stress exceeds its strength, with high mortality as a result. The effect of biomechanical load on AAA gene expression is currently not well understood.

PC230 Exosomes From Adipose-derived Stem Cells Decreased Apoptosis and Hypertrophy in Cardiac Ischemia/Reperfusion Mice

June 1, 2017 - 00:00
Cardiovascular disorders are the major health problem and the leading cause of death and disability in both industrialized and developing nations. Myocardial ischemia/reperfusion (I/R) leads to cardiomyocyte injury, including apoptosis and hypertrophy.

PC228 First Prospective Evaluation of Psychosocial Factors in Neurogenic Thoracic Outlet Syndrome

June 1, 2017 - 00:00
Neurogenic thoracic outlet syndrome (nTOS) is a complex condition caused by compression of neurovascular structures in the thoracic outlet and is often associated with chronic pain and disability. The purpose of this Institutional Review Board-approved study was to explore relationships between psychosocial factors and recovery from surgery within a cohort of nTOS patients. This is the first study to prospectively explore psychosocial functioning in nTOS patients undergoing first rib resection and scalenectomy surgery.

PC226 Predicting Stent Graft Rotation in Patient-Specific Abdominal Aortic Aneurysm Repair Using Computational Models

June 1, 2017 - 00:00
Increased use of fenestrated stent grafts has allowed more patients to benefit from this therapy; however, device rotation may occur during deployment, leading to unintended vessel occlusion. The objective of this study was to use computational models to simulate fenestrated endovascular aneurysm repair (FEVAR) within a patient-specific abdominal aortic aneurysm (AAA) in order to predict whether stent graft rotation during deployment was likely to occur.

PC224 Thrombin-Mediated Human Aortic Endothelial Barrier Dysfunction Alters MicroRNA Pathways Involved in Cell Survival, Injury, and Cancer

June 1, 2017 - 00:00
Endothelial cells (ECs) must maintain an effective physiologic barrier in a highly dynamic environment. Capable of regulating other cells within the vasculature (eg, smooth muscle cells), ECs govern response to injury and inflammation. MicroRNAs (miR) are emerging as critical regulators of vascular disease, implicating EC miRs in homeostasis maintenance. Increased EC permeability has been documented in atherosusceptible regions of the aorta, suggesting it plays a role in disease development, but whether this is a cause or consequence is unknown.

PC222 In Vitro Analysis of Antegrade in Situ Laser Fenestration of Aortic Endografts

June 1, 2017 - 00:00
In situ aortic endograft fenestrations can be performed by several methods. Retrograde laser fenestration (Lf) is used for left subclavian artery revascularization with satisfactory outcomes. We have performed antegrade fenestrations with a laser beam in the setting of complex aortic emergency repairs. The objective of this bench study was to analyze Lf performed on different aortic endografts, using microscopic and macroscopic analysis, in order to define the optimal process.

PC220 Angiotensin 1-7 Suppresses Experimental Abdominal Aortic Aneurysms

June 1, 2017 - 00:00
Abdominal aortic aneurysm (AAA) is a chronic inflammatory disease, the pathogenesis of which remains incompletely defined. We and other investigators have demonstrated the critical importance of angiotensin (Ang) II and its cellular receptor AT1 in the development of experimental AAAs. Although Ang 1-7 and its receptor Mas counteract many cellular functions mediated by AT1, the role of the Ang 1-7/Mas pathway has not been investigated in this context. This study evaluated the influences of Ang 1-7 and its receptor Mas on the formation and progression of experimental AAAs.

PC218 Cellular Effects of Tobacco Smoke Exposure in the Thoracic and Abdominal Aorta

June 1, 2017 - 00:00
Tobacco smoke exposure is a major risk factor for both aortic atherosclerosis and abdominal aortic aneurysms. The mechanism by which tobacco smoke can lead to aortic atherosclerosis and aneurysm is poorly understood. Specifically, the initial aortic changes caused by tobacco smoke have not been described, and the various contributions of nicotine and other noxious chemicals within tobacco smoke have not been differentiated. The objective of this study was to compare the cellular effects of tobacco smoke vs nicotine on human aortic smooth muscle cells (HASMCs) and to look at the histologic changes in the aorta of wild-type (WT) and hyperlipidemic (apolipoprotein E knockout) mice exposed to solubilized tobacco smoke.

PC216 Gold Nanorods As a Theranostic Platform for In Vitro and In Vivo Imaging and Photothermal Therapy of Inflammatory Macrophages

June 1, 2017 - 00:00
This study evaluated whether gold nanorods (Au NRs) can be used as a theranostic platform for dual imaging and photothermal therapy of inflammatory macrophages.

PC214 In Vivo Evaluation of Ischemia-Reperfusion Injury of Skeletal Muscle, Using 3-Carbamoyl-PROXYL-Enhanced MRI

June 1, 2017 - 00:00
Myonephropathic metabolic syndrome is caused by ischemia-reperfusion injury to skeletal muscle, following revascularization of an acute arterial occlusion in an extremity. Although ongoing research into ischemia-reperfusion injury has revealed that off-balance of the redox status plays an important role in this pathologic condition, detection of a free radical reaction at the injury site has been difficult. The purpose of this study was to evaluate a redox reaction at ischemia-reperfusion injury sites.

PC212 Role of Circulating miRNAs in Carotid Atherosclerotic Plaque Vulnerability: Implications for Stroke

June 1, 2017 - 00:00
Atherosclerotic plaque vulnerability and subsequent rupture are mediated by alterations in micro (mi)RNAs (miR) that promote inflammation and thinning of the fibrous cap, leading to carotid plaque rupture and an acute ischemic stroke. Changes in the expression of multiple microRNAs (miR) play an active role in the development of atherosclerotic plaque vulnerability. miR-27b and let7f possesses proangiogenic properties. miR-21 promotes while miR-23b inhibits vascular smooth muscle cell proliferation.

PC210 Preclinical Analysis of an Expandable Vascular Conduit for Pediatric Cardiovascular Surgery

June 1, 2017 - 00:00
Each year, >35,000 children are born in the United States with congenital heart defects. A vascular conduit is commonly used in the surgical repair of these defects. However, no currently available vascular conduit provides the potential for growth. For children with congenital heart diseases, this means having to undergo repeated operations due to the limitations of current vascular conduits. Pediatric patients with congenital cardiovascular defects would benefit greatly from an expandable conduit.

PC208 Subendothelial Matrix-Targeted Liposomal Nanoparticles for Vascular Therapeutics

June 1, 2017 - 00:00
Vascular intervention results in intimal denudation, exposure of the subendothelial matrix, and subsequent intimal hyperplasia (IH), under the control of numerous remodeling mechanisms. Reduction of IH-induced restenosis may be achieved by manipulation of these remodeling pathways through targeted molecular inhibition. Spatially controlled nanoparticles designed to colocalize to exposed subendothelial matrices could provide an optimal delivery system for targeted vascular therapeutics. To his end, we aimed to develop the framework for a surface-modified liposomal drug delivery platform designed to preferentially bind collagen type IV.

PC206 Transdifferentiation and Remodeling of a Tissue-Engineered Collagen Scaffold in the Ovine Carotid Model: An Experimental Pilot Study

June 1, 2017 - 00:00
Patch angioplasty is commonly performed after carotid endarterectomy. Although patch angioplasty is known for reduction in perioperative and long-term stroke rates as well as restenosis compared to primary closure, the ultimate patch in terms of performance and tissue remodeling is yet to be identified. This study evaluated the performance and remodeling potential of a novel tissue-engineered collagen scaffold (VascuCel) in an ovine carotid model.